GBI – Genera Biosystems Ltd.

Advanced Molecular Diagnostic Systems – Multiplex qPCR

Recombinant Cyno NKG2A & CD94 Heterodimer

Product name

NKG2A and CD94 heterodimer (KLRC1), recombinant protein

Full Product Name

Recombinant human NKG2A and CD94 heterodimeric protein (N-8His and N-DYKDDDDK)

Product synonym names

Heterodimer NKG2A and CD94; Heterodimer KLRC1 and CD94; CD159A and KLRD1 heterodimer

Product gene name

Recombinant protein KLRC1

3D structure

ModBase 3D Structure for P26715

Host: Human cells

Purity / Purification

95% as determined by reducing SDS-PAGE.

Shape / Format

Lyophilized from a 0.2 ┬Ám filtered solution of PBS, pH 7.4.

Species: Human

Endotoxin

<1.0 EU per ug as determined by the LAL test.

Fusion label

N-8His and N-DYKDDDDK

Preparation and storage

Lyophilized protein should be stored at <-20 degrees C, although stable at room temperature for 3 weeks. The reconstituted protein solution can be stored at 4-7 degrees C for 2-7 days. Aliquots of reconstituted samples are stable at <-20 degrees C for 3 months.

ISO certification

Manufactured in an ISO 9001: 2015 certified laboratory.

Other notes

Occasionally, small volumes of KLRC1 recombinant protein vial (s) may become trapped in the product vial seal during shipping and storage. If necessary, briefly centrifuge the vial in a benchtop centrifuge to dislodge any liquid on the lid of the container. Some products may need to be shipped with dry ice and an additional fee may apply for dry ice.

Related Product Information for Recombinant protein KLRC1

The type II integral membrane protein NKG2-A / NKG2-B contains 1 type C lectin domain and belongs to the family of lectin-like receptors of killer cells. The Killer cell lectin receptor family is a group of transmembrane proteins preferentially expressed in NK cells. Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation.

CD94 (Group of Differentiation 94), also known as Killer cell lectin-like receptor subfamily D member 1 (KLRD1), is expressed on the surface of natural killer cells in the innate immune system. CD94 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T cells. CD94 May form disulfide-linked heterodimer with members of the NKG2 family. The CD94 / NKG2 complex, on the surface of natural killer cells, interacts with human leukocyte antigen (HLA) -Aeon target cells.

NCBI Summary for KLRC1

Natural killer (NK) cells are lymphocytes that can mediate the lysis of certain tumour cells and virus-infected cells without prior activation. They can also regulate specific cell-mediated and humoral immunity. The protein encoded by this gene belongs to the family of lectin-like receptors of killer cells, also called the NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the orientation of the type II membrane and the presence of a type C lectin domain.

Precautions

All MyBioSource products are for scientific laboratory research purposes and not for diagnostic, therapeutic, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Product purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order when we reasonably believe that the intended use will be outside of our acceptable guidelines.

Disclaimer

While every effort has been made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be responsible for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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