Author: Bianca
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Peak pressure tapping atomic pressure microscopy for advancing cell and molecular biology
The appearance of atomic pressure microscopy (AFM) supplies an thrilling device to detect molecular and mobile behaviors below aqueous circumstances. AFM is ready to not solely visualize the floor topography of the specimens, but in addition can quantify the mechanical properties of the specimens by pressure spectroscopy assay. However, integrating AFM topographic imaging with pressure spectroscopy assay has lengthy been restricted because of...
Citation analysis of the most influential ependymoma research articles illustrates improved knowledge of the molecular biology of ependymoma
The historical past of educational analysis on ependymoma is expansive. This overview summarizes its historical past with a bibliometric evaluation of the 100 most cited articles on ependymoma. In March 2020, we queried the Net of Science database to establish probably the most cited articles on ependymoma utilizing the phrases "ependymoma" or "ependymal tumors," yielding 3145 publications. Outcomes had been organized by the variety of occasions...
Clinical application and reflection of molecular biology technology in the tertiary prevention of birth defects
Genetic components are the principle causes in prevalence of delivery defects. With deep analysis within the subject of genomics and software of molecular biology expertise, the provider standing, fetal genetic variation and postpartum screening are respectively detected from pre-pregnancy, being pregnant and post-natal screening (earlier than onset of illness) underneath excellent three-level prevention and management system for delivery...
Connecting chemistry and biology through molecular descriptors
By means of the illustration of small molecule buildings as numerical descriptors and the exploitation of the similarity precept, chemoinformatics has made paramount contributions to drug discovery, from unveiling mechanisms of motion and repurposing authorised medicine to de novo crafting of molecules with desired properties and tailor-made targets. But, the inherent complexity of organic programs has fostered the implementation of large-scale...
Systems biology approaches to unravel the molecular and genetic architecture of Alzheimer’s disease and related tauopathies
Over time, genetic research have recognized a number of genetic danger variants related to neurodegenerative problems and helped reveal new organic pathways and genes of curiosity. Nevertheless, genetic danger variants generally reside in non-coding areas and should regulate distant genes reasonably than the closest gene, in addition to a gene's interplay companions in organic networks. Methods biology and practical genomics approaches present...
Molecular biology of autoinflammatory diseases
The lengthy battle between people and varied bodily, chemical, and organic insults that trigger cell damage (e.g., merchandise of tissue harm, metabolites, and/or infections) have led to the evolution of assorted adaptive responses. These responses are triggered by recognition of damage-associated molecular patterns (DAMPs) and/or pathogen-associated molecular patterns (PAMPs), normally by cells of the innate immune system. DAMPs and PAMPs are...
fd-rapid-timmstain
Timm's silver sulfide method has hitherto been considered a very sensitive technique for demonstrating metal ions, particularly zinc, in the central nervous system. The principle of this technique is that the metals in the tissue can be histochemically transformed into metal sulphides. Subsequently, metal sulfides catalyze the reduction of silver ions by a reducing agent to metal grains that are visible under an optical or electron microscope....